Genes and Development

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GENES & DEVELOPMENT 22:1719-1723, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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PERSPECTIVE

Signaling silence—breaking ground and spreading out

Hye Ryun Woo and Eric J. Richards1

Department of Biology, Washington University in St. Louis, St. Louis, Missouri 63130, USA

Among the persistent mysteries in epigenetics are the criteria by which specific regions of the genome are chosen for deposition of distinguishing chromatin marks. Once a particular region is modified, will the newly acquired epigenetic state spill onto neighboring regions of the genome or be confined to tidy patches? The report by Henderson and Jacobsen in the the previous issue of Genes & Development (1597–1606) addresses these questions while providing insight into the utility of DNA methylation for a eukaryotic genome.

[Keywords: Epigenetics; DNA methylation; siRNA; gene silencing]

1 Corresponding author.

E-MAIL richards{at}wustl.edu; FAX (314) 935-4432.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1694608.


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Related Article

Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading
Ian R. Henderson and Steven E. Jacobsen
Genes & Dev. 2008 22: 1597-1606. [Abstract] [Full Text] [PDF]





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