Genes and Development Attend a BioResearch Product Faire

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

GENES & DEVELOPMENT 22:1737-1740, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Blau, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blau, J.
Related Content
Right arrow Post-transcriptional Control
Right arrow Cell Biology
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

PERSPECTIVE

PERspective on PER phosphorylation

Justin Blau1

Department of Biology, New York University, New York, New York 10003, USA

Period (PER) proteins are essential parts of the molecular clocks that control circadian rhythms in flies and mammals. Phosphorylation regulates PER’s stability and subcellular localization; however, the physiologically relevant sites have been difficult to identify in spite of knowing the relevant kinase. In this issue of Genes & Development, Chiu and colleagues (1758–1772) identify a key phosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set clock speed.

[Keywords: Circadian rhythms; Drosophila; PER; β-TrCP/SLIMB; CK1{varepsilon}/DBT; F-box protein; phosphorylation]

1 Correspondence.

E-MAIL justin.blau{at}nyu.edu; FAX (212) 995-4015.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1696408.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock
Joanna C. Chiu, Jens T. Vanselow, Achim Kramer, and Isaac Edery
Genes & Dev. 2008 22: 1758-1772. [Abstract] [Full Text] [PDF]





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genome Res. Learn. Mem.
Protein Science RNA Genes Dev.
Copyright © 2008 by Cold Spring Harbor Laboratory Press.